TWO people were arrested for drug offences and two knives were seized in a police crackdown in Melbourne's south last night.

Almost 100 penalty notices were also issued for traffic and public transport-related offences as part of Operation Guardian, aimed at reducing attacks on international students and anti-social behaviour.

The pair was arrested at Highett train station.

Acting Insp Mark Zervaas said more than 75 police took to the streets of the Kingston area.

"We had a high visible police presence across our local railway stations between Carrum and Moorabbin, shopping centres and late-night venues targeting anti-social behaviour and persons responsible for assaults and robberies," Acting Inspector Zervaas said.

And police said more "targeted campaigns" were on the cards.

"Victoria Police is committed to working together with the community to create a safer area for all who live and visit here,'' Acting Inspector Zervaas said.

Officers from the state highway patrol, operational response unit, transit and local police were involved in the blitz.

The cities of Moreland, Brimbank, Maribyrnong, Dandenong, Melbourne and Darebin have already been targeted as part of Operation Guardian.

Chief Commissioner Simon Overland said police would target trouble-makers when officers took over train lines as part of Guardian.

"We won't necessarily be warning people where we're doing this, when we're doing this. It'll just happen," he said in July.